In an instant, it’ll transform from a simple side into a show-stopping main dish. But you could also load the squash with a flavorful filling after it comes out of the oven. You could leave them empty, roast the squash, and serve it as a side dish. After you scoop out the seeds, the squash halves form natural bowls. Acorn squash presents us with a unique opportunity. When people ask me what to serve as a vegetarian main dish at Thanksgiving, I always reply, “Stuffed acorn squash!” I love putting seasonal produce at the center of my plate whenever I can, and Thanksgiving dinner is no exception.